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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, “very effective” and “best-in-class” are not the same conversation
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in the study with non-obese euthyroid individuals, including 1402 AIT patients and 4206 sex-, age-, and body mass index (BMI)-matched healthy controls, showed that TPOAb levels was positively associated with total cholesterol (TC), triglycerides (TG), and homeostatic model assessment for insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein (hsCRP) concentrations
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