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Reuptake controls the amount in the synapse, and the recycled norepinephrine can either be broken down by enzymes (COMT or MAOA) or it can be packaged into vesicles to be released again.[ref] Related article: MAO-A & MAO-B Related article: COMT gene variants and neurotransmitter metabolism Norepinephrine Transporter (NET): Regulating norepinephrine levels in the synapse Similar to dopamine and serotonin, norepinephrine levels in the synapse are tightly regulated by reuptake into presynaptic neurons
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