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Peptides More Likely to Cause Site Reactions While most patients tolerate peptides well, the following are more likely to cause localized reactions , especially in sensitive individuals: CJC-1295 (with DAC) – tends to be more inflammatory than without DAC LL-37 – antimicrobial peptides can activate immune cells at the injection site KPV – rare but possible immune stimulation during early use Thymosin Alpha 1 – due to its immunomodulatory effects GHK-Cu – may irritate if not well diluted Discuss any sensitivities or history of skin reactions with your provider before starting therapy