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It is possible that acetaldehyde, because of its ability to covalently bind proteins, can form adducts with the PPAR-α transcription complex, thereby preventing its ability to bind the promoter element(s).[28,29] Adiponectin in Alcohol Liver Disease In addition to PPAR-α, hepatic lipid metabolism has been shown to be tightly regulated by adiponectin and adenosine monophosphate-activated protein kinase (AMPK)
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