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However, paracrine expression of these components is also important during ovine folliculogenesis, and the local level of IGF is enhanced by the decreased expression of IGF biding proteins (IGFBP-2,-3,-4,-5, and−6) in growing follicles, as they advance from potential atresia to follicle selection (55)
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Disturbed mitochondrial function is both age and IPF-related, suggesting that an increase in mitochondrial ROS production could cause fibrotic lung damage by transforming growth factor-β (TGF-β) signaling and NADPH oxidase 4 activation
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