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As fitting function, the following equation was used where M z (t) is the longitudinal relaxation at the recovery delay time t , M 0 is the equilibrium magnetization and R i is either the longitudinal relaxation rate R 1 or R 1ρ
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Of note, the MAGNIMS criteria have proposed using a definition for radiologically isolated syndrome less stringent than the Okuda criteria, with patients needing to meet only radiological dissemination in space criteria and be without typical multiple sclerosis symptoms (22)
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