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The translocation of LPS also triggers the toll-like receptor 4 (TLR4)/NF-ΞΊB signaling pathway in Kupffer cells, promoting the secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-Ξ±) and IL-6, and sustaining the inflammatory milieu associated with liver injury and fibrosis [6, 16]
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