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qRT-PCR analysis (Figure 2E) showed that FOXO4-DRI-treated PDL9 cells displayed enhanced SOX9 expression, and reduced MMP12 and MMP13 expression, which however were at the expense of lower expression levels of COL2

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Although both these studies are very preliminary, the data obtained suggested that ALA treatment could be a successful “neuroprotective” treatment option for AD and related dementias