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For this reason, patients with a history of immunoglobulin (Ig) E–mediated (allergic or anaphylactic) reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides such as celecoxib, chlorthiazide, furosemide and others without elevated risk of an IgE-mediated reaction compared with the general population

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“Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption”