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For example, the use of N-acetylcysteine (NAC), a well-known antioxidant, has been shown to reduce ROS levels by more than 40% and increase antioxidant enzyme activities, thereby alleviating liver injury in sepsis models ( 3.3 Mitochondrial dysfunction Mitochondrial dysfunction represents a critical factor contributing to disturbances in liver energy metabolism and organ damage during sepsis ( LPS, through the activation of hepatic cells, induces an overproduction of ROS, which causes damage to the mitochondrial membrane

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