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Some of the most common include: Bone marrow disorders such as aplastic anemia or myelodysplastic syndrome Cancers like leukemia or lymphoma that affect the marrow directly Autoimmune diseases where the body attacks its own marrow cells Infections such as HIV, tuberculosis, or viral hepatitis that suppress bone marrow activity Vitamin deficiencies, particularly Vitamin B12 or folate deficiency Side effects of certain medications or chemotherapy that damage the marrow Exposure to toxins or radiation that interfere with cell production Identifying the exact cause is crucial because treatment depends on the underlying condition