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In approximately 3.4/100 patients Tysabri use is associated with the development of progressive multifocal leukoencephalopathy (PML), a potentially fatal complication
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The cell’s ability to biosynthesize GSH is controlled by various factors, including intracellular substrate utilization (L-cysteine), GCL activity, rate-limiting enzymes in GSH synthesis, and GSH feedback inhibition of GCL (Haddad et al., 2021)
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