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Glutathione Degradation Is a Key Determinant of Glutathione Homeostasis - PMC

We have proposed a protective role for DT-diaphorase against aminochrome neurotoxicity, which is supported by cell culture studies based on the inhibition of DT-diaphorase with dicoumarol and the induced aminochrome neurotoxicity that results from reduced DT-diaphorase expression by siRNA [38, 41, 42, 46]

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In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice (Yang et al., 2023)