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Estrogen receptor alpha upregulates the system Xc- components SLC7A11 and SLC3A2 in ER + breast cancer cells, enhancing the cells’ resistance to ferroptosis and reducing sensitivity to endocrine therapy, suggesting that targeting the estrogen-regulated system Xc- may promote ferroptosis and improve therapeutic efficacy (218)
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Size:30ml (1 fl. oz.)
[DOI] [PubMed] [Google Scholar] Giovanni J.D., Sun T., Sheng Z.H
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