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How This Works Tirzepatide is a dual GLP-1/GIP receptor agonist : it activates both the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) incretin receptors, which together regulate appetite, glucose-dependent insulin release and glucagon [1] [5]

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Half-life ~30 min plasma half-life reported in rat models (subcutaneous administration)